Explore the Benefits of Nicotinamide Mononucleotide (NMN) for Anti-Aging: Dosage, Research
Why we need Nicotinamide Mononucleotide(NMN)
As we age, our bodies go through a series of changes that can lead to a decline in overall health and well-being. But what if there was a way to slow down or even reverse the aging process? Nicotinamide Mononucleotide (NMN) may hold the key to living a longer, healthier life.
NMN is a NAD+ precursor, a crucial biomarker in human cells. As we age, NAD+ levels decline due to enzymatic functions. However, supplementing with NMN can help to improve cellular function and increase NAD+ levels, potentially slowing down the aging process.
But what sets NMN apart from other anti-aging treatments? Unlike many other options, NMN has minimal side effects and is well-tolerated. Learn more about the potential of NMN for anti-aging and how it can improve your lifespan."
What is Nicotinamide Mononucleotide(NMN)
Nicotinamide Mononucleotide (NMN) is a molecule that plays a crucial role in the human body's energy metabolism. It is derived from niacin and is a product of the reaction between nicotinamide ribose and a phosphate group. NMN is a substrate for the enzyme nicotinamide mononucleotide adenylyltransferase, which converts it to NAD+ (nicotinamide adenine dinucleotide), a fundamental molecule in cellular biochemical functions.
Recent preclinical studies have shown that NMN may have therapeutic potential in reversing the aging process and managing cancer. As a precursor of NAD+, a decline in NMN levels can have a drastic effect on overall health. The research on NMN's role in anti-aging and cancer management is promising and ongoing.
What foods contain Nicotinamide Mononucleotide(NMN)
Broccoli, Cabbages, Edamame, Mushroom, Tomatoes, Avocado, Cucumber, Shrimp, Raw Beef
What are the benefits of Nicotinamide Mononucleotide(NMN)
- Anti-Aging Supplement: Research by Dr. David Sinclair of Havard University has confirmed the efficiency of NMN in slowing down aging. This can improve memory and cognitive function. The decline in NAD+ levels as we age can lead to a decline in energy production by the mitochondria. NMN can help to increase NAD+ levels in the body and activate sirtuins, which are enzymes that play a crucial role in aging and longevity. By improving cellular function, NMN can help to slow down the aging process and improve overall health and wellness.
- Treatment of Diabetes II: NMN can improve glucose intolerance and insulin sensitivity in patients with diabetes. A decline in NAD+ levels can trigger type II diabetes. By administering NMN, it can significantly improve glucose intolerance and insulin sensitivity in patients with diabetes. Additionally, some geneticists inferred that the treatment reverses the gene expression that’s due to a high-fat diet.
- Neuroprotection: NMN can protect the brain from damage and improve cognitive function, making it a potential treatment for Alzheimer's disease, Parkinson's syndrome, and dementia. When NAD+ levels fall, the mental state lies at stake. Administering NMN optimizes the quantity of NAD+, hence protecting the brain from damage. It can improve neuronal functions and cognition, including, learning, and memory.
- Improved Metabolism: Optimal NMN levels in the body can increase NAD+ and improve metabolism, potentially helping with weight loss and reducing the risk of obesity, diabetes, fatty liver, and dyslipidemia. NAD+ regulates energy metabolic functions, repair of DNA, and response to stress. NMN directly affects metabolism and its deficiency would trigger several metabolic conditions. In the case of glucose intolerance, NMN steps in to enhance the metabolism of sugar. Research confirms that you can lose up to 10% of your bodyweight if you take NMN.
- Upholding Youthfulness: NMN can reverse the vascular atrophy and senescence of blood vessels, improving blood flow and muscle endurance, and slowing down the aging process. NMN is the key regulator of SIRT1, which is a protein that plays a crucial role in maintaining blood flow and muscle endurance. When the human endothelial cells suffer a decline in SIRT1 proteins, blood flow will drastically fall. By administering NMN, it can activate sirtuin-signaling, which will generate new capillaries to supply oxygen and nutrients to the muscles and other vital organs. This can help to improve muscle endurance, slow down the aging process, and improve overall health and wellness.
NMN Vs NR
Understanding the Differences Between Nicotinamide Mononucleotide (NMN) and Riboside
Both Nicotinamide Mononucleotide (NMN) and riboside are precursors of NAD+, a crucial molecule in cellular biochemical functions. However, there are some key differences between the two compounds.
One of the main differences is their molecular size. NMN has a larger molecular size than riboside, which means that riboside can pass through the human body without breaking down its whole molecule. However, recent studies have discovered a mysterious transporter called Scl12a8 protein which facilitates the conversion of NMN to NAD+.
Another difference is the price, NMN is typically slightly more expensive than riboside. However, it's worth noting that more research is needed to fully understand the differences and benefits of these compounds.
Nicotinamide Mononucleotide(NMN) Research
Nicotinamide Mononucleotide (NMN) is a molecule that has been the subject of numerous research studies since its discovery in 1963. It has been found to have potential benefits for anti-aging, cardiovascular health, neurodegeneration, physiological and immunological functions, and more. Here are a few notable research studies on NMN:
- Anti-Aging: In 2013, Dr. David Sinclair from Harvard University found that NMN can improve muscle capacity and metabolism in mice models. He also found that it was as effective as working out, and did not have any side effects.
- Cardiovascular Health: In 2014, Yamamoto and his associates found that NMN has cardio-protective properties, and can protect the heart from reperfusion and ischemic injury. In 2016, De Picciotto and his team found that it can also promote vascular functionality.
- Neurodegeneration: In 2015, Long and his team found that NMN can treat Alzheimer's disease and reduce its symptoms. In 2016, Wang and his team found that it can also counter cognitive disorders and neural impairment.
- Physiological and Immunological Functions: In 2013, Mills and his team found that NMN can manage type II diabetes. In 2016, he found that it can also counter physiological and immunological decline in old mice, and reduce oxidative stress.
- Mysterious Transporter: In recent years, Imai and his team discovered a protein called Slc12a8 that aids in the assimilation of NMN into the body, which can increase its bioavailability.
- Clinical Trials: Since 2017, Scholars from Keio University in Tokyo and Washington University have been conducting clinical trials on NMN among aged but healthy subjects. The aim is to establish the safety of the supplement and understand how it affects beta-cell functions and if there are any side effects.
Nicotinamide Mononucleotide(NMN) Dosage
When it comes to taking Nicotinamide Mononucleotide (NMN) supplements, one of the most common questions is "How much should I take?". The recommended dosage for NMN varies depending on the source, but generally ranges from 25mg to 300mg per day.
In most clinical trials on NMN, the subjects were given a maximum of 250mg per day. Dr. Sinclair, a leading researcher in the field, takes about 750mg of NMN per day. Some users have reported taking up to 1000mg per day, but it's important to note that there are no known side effects associated with NMN.
It's always recommended to start with the lowest dosage possible and gradually increase it as needed.
Is Nicotinamide Mononucleotide safe? A look at the current research
When it comes to the safety of Nicotinamide Mononucleotide (NMN), the current research suggests that it is safe to use. To date, there is no evidence to indicate that NMN is unsafe. In fact, clinical trials on NMN have not reported any serious side effects in the subjects. Additionally, preclinical studies on NMN have also been successful without reporting any adverse symptoms. However, it's always important to consult with a healthcare professional before taking any supplement, especially if you have any underlying health conditions or are taking any medications.
Nicotinamide Mononucleotide(NMN) Supplement
As Nicotinamide Mononucleotide (NMN) has not yet received full endorsement by the FDA, it cannot be prescribed as a drug. However, it can be taken as a dietary supplement. While you may be able to find it in local drug stores, the best place to purchase NMN is online from a reputable supplier. You can choose to buy NMN in bulk powder for research purposes or as a dietary supplement.
To enhance its bioavailability, it's recommended to take NMN in sublingual form (under the tongue) rather than oral tablets. According to FDA standards, a person needs a minimum of 560mg of NMN per day. While certain foods like broccoli and cabbage contain small amounts of NMN, it would be impossible to consume the large quantities necessary to meet the FDA requirements. Therefore, purchasing a supplement from a reputable supplier is the most practical option.