ANTI-CANCER

Anti-cancer - Inhibition of Tumor Growth Rate and Metastasis by Fullerene C60

S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy1, U. Ritter, P. Scharff
Joint Ukrainian-German Center on Nanobiotechnology,
Taras Shevchenko National University of Kyiv, Institute of Biology,
Volodymyrska Str., 64, 01601 Kyiv, Ukraine
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine,
Vasylkivska Str. 45, 03022 Kyiv, Ukraine
Technical University of Ilmenau, Laboratory of Chemistry, 09684 Ilmenau, Germany
Experimental Oncology 33, 162–164, 2011 (September)

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Summary:

Results: The C60 FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%.

Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.

Key Words: Water-soluble pristine С60 fullerenes, Lewis lung carcinoma, tumor growth.

Conclusion:

The C60FAS containing hydrated single C60 molecules and C60 clusters with size up to ~2.8 nm without showing direct cytotoxicity at low single therapeutic dose of 5 mg/kg demonstrates the inhibition of growth of transplanted tumor (antitumor effect):

The maximum therapeutic effect was determined as 76.5% in Experiment 1 and 25.1% in Experiment 2.

The increase of animal life span by 21.8% was found in Experiment 2.

The metastasis inhibition index was obtained as 48% (antimetastatic effect, Experiment 3).

Finally, the anticancer affect of C60FAS was confirmed by histological data for the animal tumors of control and investigated group in Experiment 3.

The obtained results can be explained as a result of the high antioxidant activity of C60 fullerenes, neutralizing excess reactive oxygen species in the cell, and possibly blocking the specific cell receptors, for example, endothelial growth factor receptors.

The proposed method of C60FAS application for the inhibition of tumor growth is promising for experimental oncology and may be tested in the future studies.

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