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NMN tips and Advices


Summary of this article:

Key Points Details
Tip 1 Avoid storing NMN in the refrigerator to prevent moisture absorption.
Tip 2 Opt for sublingual NMN powder for direct absorption into the bloodstream.
Tip 3 Consider taking NMN with food for a potential energy boost.
Tip 4 Consume foods that naturally contain NMN, such as broccoli, cucumbers, and avocados.
Tip 5 Gradually increase your NMN dosage until you achieve desired results.
Tip 6 Start with a higher dose if you're on a budget, then reduce to maintain NAD levels.
Tip 7 Pair NMN with a sirtuin activator like Olive oil, Resveratrol or Quercetin.
Tip 8 Engage in exercise to activate the AMPK pathway and recycle NAD.


So, you're either already using Nicotinamide Mononucleotide (NMN) or contemplating its use, and you're keen to optimize its benefits. Today, we will provide you with crucial tips to boost those outcomes. Some of these suggestions might contradict what you've previously heard or been advised, but we'll clarify why that might be the case.

You're after results, and sometimes achieving those requires unconventional approaches, a bit of rule-bending, or deviating from what you've been led to believe is the 'right' way. There are reasons why you've been given certain advice, but we are here to shed light on why those reasons might not align with your specific goals and desired outcomes. Remember, our ultimate aim is to achieve the best possible results.

Tip Number 1 - Avoid Storing NMN in the Refrigerator

The first piece of advice we have for you is to refrain from storing your Nicotinamide Mononucleotide (NMN) in the refrigerator. We understand that this contradicts what you've likely been told, and we are aware that your NMN was probably refrigerated during storage before it reached you. Let us explain why this might not be the best approach.

Refrigeration can indeed be beneficial for a crystallized molecule like NMN. Crystals can degrade due to environmental changes, such as fluctuations in temperature. This process, known as aging, can accelerate the deterioration of these molecules and potentially reduce their effectiveness. The rationale behind refrigerating NMN is to maintain a stable environment, as external temperatures and conditions can vary.

However, once you've opened your NMN, it's best not to store it in the fridge. Think about it like potato chips or dried fruits; you wouldn't typically refrigerate these items. Nicotinamide Mononucleotide (NMN) is a dried product, you want to maintain its dryness.

If you're taking NMN daily, possibly multiple times a day like we do, each time you remove it from the fridge and expose it to a warmer environment, you're potentially introducing moisture. Let us explain how condensation forms. Each time you take your NMN out of the fridge and open it in a warm room, you're exposing it to condensation and thus increased moisture.

So, to maintain the integrity of your NMN, it's best to store it in a dry, stable environment, not in the refrigerator.

Tip Number 2 - Opt for Sublingual NMN Powder

Choosing to take Nicotinamide Mononucleotide (NMN) in a sublingual form can be a game-changer in your supplement routine. Sublingual intake involves placing the NMN powder under your tongue and allowing it to dissolve naturally. This method is highly effective because it allows the NMN to be absorbed directly into your bloodstream. This bypasses the digestive system, which can sometimes reduce the effectiveness of certain supplements. By taking NMN sublingually, you ensure that a higher concentration of the supplement enters your bloodstream, potentially enhancing its benefits. This method can be particularly beneficial for those seeking to maximize the impact of their NMN intake. So, if you're looking to optimize your Nicotinamide Mononucleotide (NMN) supplementation, consider switching to a sublingual NMN powder.

Tip Number 3 - Consider Taking NMN Alongside Food

The third tip might contradict what you've heard, even from experts like David Sinclair, but hear us out. If you're looking to boost the benefits of Nicotinamide Mononucleotide (NMN), consider taking it with food. If you're among the 10-20% of people who don't feel a noticeable energy boost or other effects from NMN, try consuming it right after eating high-energy foods like an apple or a banana.

From personal experience, we have found that taking NMN after eating high-energy foods gives me a significant energy surge, almost like having one too many cups of coffee. So, we suggest breaking the 'empty stomach' rule at least once a day if you're looking to enhance your NMN results.

The reason you're often advised to take NMN on an empty stomach is to align its intake with your circadian rhythms, as your NAD levels naturally rise in the morning. However, we have noticed that especially in the afternoon, if we forget to take NMN and then remember after eating, the subsequent energy boost is almost overwhelming.

So, if you're not experiencing the desired results from NMN, try taking it after a meal. It is safe to consume Nicotinamide Mononucleotide (NMN) with food, and it might just give you the boost you're looking for. Let us know in the comments if this approach works for you. Remember, this is all about finding what works best for your body.

Tip Number 4 - Consume Foods That Naturally Contain the Supplements You're Taking

The fourth tip is to incorporate into your diet foods that naturally contain the supplements you're taking. For instance, Nicotinamide Mononucleotide (NMN) is naturally found in foods like broccoli, cucumbers, and avocados. You might wonder why you should eat these foods if you're already taking the supplement. Well, there are several benefits to doing so.

We instinctively began eating foods associated with the polyphenols we were taking, such as Resveratrol, TMG, NMN, and Isaphysatin. One reason for this is that if these substances are beneficial and we are taking them as supplements, it makes sense to also get some from natural food sources. This can enhance and increase the benefits.

Moreover, consider metabolism. Our bodies have been consuming these polyphenols from foods for thousands of years. We are biologically programmed to extract these substances from the foods we eat. Therefore, your body is likely to recognize, metabolize, and process these polyphenols more effectively when they come from food, rather than when they're taken alongside unhealthy or processed foods.

Additionally, consuming healthy foods provides natural benefits. You'll get sustained energy from these foods, and you're less likely to crave unhealthy foods. This can enhance your physical results by potentially helping you lose weight and feel better for longer periods. So, our third tip is to eat foods that naturally contain the supplements you're taking.

Tip Number 5 - Gradually Increase Your NMN Dosage Until You Achieve Desired Results

The fifth tip is to incrementally increase your Nicotinamide Mononucleotide (NMN) dosage until you start to feel the desired effects. Everyone's body responds differently to varying levels of NMN. Studies have shown that NMN is safe to consume up to a couple of grams per day, but you might not experience noticeable results at lower doses.

Speaking from personal experience, we found that our results improved as we increased our dosage. However, there was a point of diminishing returns beyond 1 to 1.5 grams. We currently take 1 grams. We were feeling fantastic at 1.5 grams, but we are not sure if we even need that much. Over time, your body will accumulate increased NAD levels anyway.

So, if you're not experiencing the desired results, you might be taking too little. For instance, you might be taking 500 milligrams, but you might actually need a gram to significantly raise your NAD levels and experience the energy, focus, and weight loss benefits that many people associate with NMN. Remember, this advice applies to the vast majority of people, but individual results may vary.

Tip Number 6 - Start with a Higher Dose If You're on a Budget

The sixth tip might seem to contradict the first one, especially if you're budget-conscious and find Nicotinamide Mononucleotide (NMN) to be a bit pricey. If you're keen to try NMN but are concerned about the cost, you might have decided to budget for a smaller dose, say 250 milligrams. However, our sixth tip is to start with a higher dose, even if just for a short period.

Consider taking 500 milligrams for the first week, then reduce to your budgeted amount of 250 milligrams. Yes, this approach will initially cost a bit more, but it's important to note that it takes about nine days for your NAD levels to stabilize once you start taking NMN. After that, you don't need as much to maintain those levels. This information comes from recent interviews with David Sinclair.

By taking 500 milligrams for about a week, you might be able to reduce your dosage to 250 milligrams and still experience the benefits. So, if you're on a budget but still want to enhance your Nicotinamide Mononucleotide (NMN) results, give this approach a try.

Tip Number 7 - Pair NMN with a Sirtuin Activator

The seventh tip is to take Nicotinamide Mononucleotide (NMN) in conjunction with a sirtuin activator, such as Olive oil, Resveratrol or Quercetin. Some studies suggest that excessive Resveratrol intake can lead to a decrease in energy.

If you suffer from allergies, you might want to consider alternating between Resveratrol and Quercetin. This approach allows you to avoid overloading on one supplement and provides a balanced mix of the two.

Olive oil is another excellent natural sirtuin activator that we try to consume regularly.

Of course our C60 olive oil is a must with Nicotinamide Mononucleotide (NMN).

Alternatively, you could take Resveratrol or Fisetin. However, if you opt for Fisetin, especially in high doses, we wouldn't recommend combining it with Resveratrol or Quercetin. When taking Fisetin, you have to choose not to take any Resveratrol or Quercetin during this period. We also avoid Spermidine, as it's a senolytic, and we don't believe we need to eliminate any more senescent cells.

Sirtuins are proteins that NAD uses to repair DNA and enhance mitochondrial performance. By taking a sirtuin activator along with Nicotinamide Mononucleotide (NMN), you can enhance these downstream benefits.

Tip Number 8 - Engage in Exercise to Activate the AMPK Pathway

The eighth and arguably most crucial tip for enhancing your Nicotinamide Mononucleotide (NMN) results involves recycling the NAD already present in your body. We take NMN to increase NAD levels, hence why we sometimes use these terms interchangeably. Exercise activates your AMPK (adenosine monophosphate-activated protein kinase) pathway.

Exercise offers numerous benefits to your skeletal system, muscles, cells, and joints. It's a case of 'use it or lose it' when it comes to exercise, and it also aids in metabolizing everything you're consuming, ensuring you extract maximum energy. The AMPK pathway helps recycle the NAD you already have.

If you're not exercising, or engaging in other activities like cold shower therapy, sauna sessions, intermittent fasting, or time-restricted feeding, you're not activating the AMPK pathway as effectively. We personally follow a time-restricted feeding schedule, eating only between 12 AM and 8 PM, to create additional cellular stress. All these activities help activate the AMPK pathway, recycling the NAD you already have. If you're not exercising or engaging in these activities, you're not recycling NAD as efficiently, and you won't derive as much benefit from your NMN supplement.


We personally consume pure Nicotinamide Mononucleotide (NMN) and we recommend you do the same. Regardless of where you source your NMN, ensure it's pure. The method of intake is not as important as the quality. Once you consume it, your NAD levels will start to increase within a few minutes, and as mentioned earlier, they will stabilize after about nine days. So, once you start boosting your NAD levels, aim to maintain that for at least a week or two. We hope these tips assist you in achieving the results you're looking for.

Frequently Asked Questions

What is the best way to store NMN?

It's recommended to store NMN in a dry, stable environment, not in the refrigerator to prevent moisture absorption.

What is the best form of NMN to take?

Sublingual NMN powder is highly recommended as it allows for direct absorption into the bloodstream.

Should I take NMN with food?

Yes, taking NMN with high-energy foods can potentially boost its benefits.

What foods naturally contain NMN?

Foods like broccoli, cucumbers, and avocados naturally contain NMN.

How should I adjust my NMN dosage?

It's suggested to gradually increase your NMN dosage until you start to feel the desired effects.

How can I afford NMN if I'm on a budget?

Start with a higher dose for the first week, then reduce to your budgeted amount to maintain NAD levels.

What should I pair with NMN?

Pair NMN with a sirtuin activator like Olive oil, Resveratrol or Quercetin for enhanced benefits.

How can I recycle NAD in my body?

Engage in exercise to activate the AMPK pathway and recycle NAD.

What are the benefits of taking NMN?

NMN can help increase NAD levels, potentially enhancing energy, focus, and weight loss benefits.

How long does it take for NAD levels to stabilize after taking NMN?

It takes about nine days for NAD levels to stabilize after starting NMN supplementation.

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